Proteomic Modulation in TGF-β-Treated Cholangiocytes Induced by Curcumin Nanoparticles.

ABSTRACT: Curcumin is a natural polyphenol that exhibits a variety of beneficial effects on health, including anti-inflammatory, antioxidant, and hepato-protective properties. Due to its poor water solubility and membrane permeability, in the present study, we prepared and characterized a water-stable, freely dispersible nanoformulation of curcumin. Although the potential of curcumin nanoformulations in the hepatic field has been studied, there are no investigations on their effect in fibrotic pathological conditions involving cholangiocytes. Exploiting an in vitro model of transforming growth factor-β (TGF-β)-stimulated cholangiocytes, we applied the Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS)-based quantitative proteomic approaches to study the proteome modulation indu

SUBMITTER: Ceccherini E 

PROVIDER: S-EPMC10341614 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature