Repurposing Simvastatin in Parkinson's Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the Substantia nigra.

ABSTRACT: Parkinson's disease is a neurodegenerative disorder characterized by oxidative stress and immune activation in the nigro-striatal pathway. Simvastatin regulates cholesterol metabolism and protects from atherosclerosis disease. Simvastatin-tween 80 was administered 7 days before sterotaxic intrastriatal administration of MPP⁺ (1-methyl-4-phenylpyridine) in rats. Fluorescent lipidic product formation, dopamine levels, and circling behavior were considered damage markers. Twenty-four hours and six days after, the animal group lesioned with MPP⁺ showed significant damage in relation to the control group. Animals pretreated with simvastatin significantly reduced the MPP⁺-induced damage compared to the MPP⁺ treated group. As apoptosis promotes neuroinf

SUBMITTER: Rubio-Osornio M 

PROVIDER: S-EPMC10341642 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature