Are Therapies That Target α-Synuclein Effective at Halting Parkinson's Disease Progression? A Systematic Review.

ABSTRACT: There are currently no pharmacological treatments available that completely halt or reverse the progression of Parkinson's Disease (PD). Hence, there is an unmet need for neuroprotective therapies. Lewy bodies are a neuropathological hallmark of PD and contain aggregated α-synuclein (α-syn) which is thought to be neurotoxic and therefore a suitable target for therapeutic interventions. To investigate this further, a systematic review was undertaken to evaluate whether anti-α-syn therapies are effective at preventing PD progression in preclinical in vivo models of PD and via current human clinical trials. An electronic literature search was performed using MEDLINE and EMBASE (Ovid), PubMed, the Web of Science Core Collection, and Cochrane databases to collate clinical evidence that investig

SUBMITTER: Rodger AT 

PROVIDER: S-EPMC10341763 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature