Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma.

ABSTRACT: Nudt2 encodes a diadenosine tetraphosphate (Ap₄A) hydrolase that catalyzes the hydrolysis of Ap₄A and is involved in the lysyl tRNA synthetase-Ap₄A-Nudt2 (LysRS-Ap₄A-Nudt2) signaling pathway. We have previously demonstrated that this pathway is active in non-small cell lung cancer. Nudt2 was shown to be involved in cell proliferation in breast cancer, making it an important target in cancer therapy. Currently, the function of Nudt2 in malignant melanoma has not been demonstrated. Therefore, we investigated the role played by Nudt2 in the growth of human melanoma. Our study showed that Nudt2 knockdown suppressed anchorage-independent growth of human melanoma cells in vitro. The in vivo effect of Nudt2 was determined by investigating the role playe

SUBMITTER: Hidmi S 

PROVIDER: S-EPMC10341887 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature