The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left-Right Functional Differences.

ABSTRACT: Breast cancer is a complex and heterogeneous disease that displays diverse molecular subtypes and clinical outcomes. Although it is known that the location of tumors can affect their biological behavior, the underlying mechanisms are not fully understood. In our previous study, we found a differential methylation profile and membrane potential between left (L)- and right (R)-sided breast tumors. In this current study, we aimed to identify the ion channels responsible for this phenomenon and determine any associated phenotypic features. To achieve this, experiments were conducted in mammary tumors in mice, human patient samples, and with data from public datasets. The results revealed that L-sided tumors have a more depolarized state than R-sided. We identified a 6-ion channel-gene signatur

SUBMITTER: Masuelli S 

PROVIDER: S-EPMC10342022 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature