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Improvements in Systemic Therapies for Advanced Malignant Mesothelioma.


ABSTRACT: Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy associated with poor prognosis and a 5-year survival rate of 12%. Many drugs have been tested over the years with conflicting results. The aim of this review is to provide an overview of current therapies in MPM and how to best interpret the data available on these drugs. Furthermore, we focused on promising treatments under investigation, such as immunotherapy with targets different from anti-PD-1/PD-L1 inhibitors, vaccines, target therapies, and metabolism-based strategies.

SUBMITTER: Deiana C 

PROVIDER: S-EPMC10342038 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Improvements in Systemic Therapies for Advanced Malignant Mesothelioma.

Deiana Chiara C   Fabbri Francesca F   Tavolari Simona S   Palloni Andrea A   Brandi Giovanni G  

International journal of molecular sciences 20230621 13


Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy associated with poor prognosis and a 5-year survival rate of 12%. Many drugs have been tested over the years with conflicting results. The aim of this review is to provide an overview of current therapies in MPM and how to best interpret the data available on these drugs. Furthermore, we focused on promising treatments under investigation, such as immunotherapy with targets different from anti-PD-1/PD-L1 inhibitors, vaccine  ...[more]

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