Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery.

ABSTRACT: The pathophysiology of body weight control involves complex interactions between hormonal, environmental, behavioral and genetic factors. The purpose of this study was to analyze the association between single nucleotide polymorphisms (SNPs) of 13 genes encoding gastrointestinal peptides, their receptors or the proteins involved in their expression, with long-term weight response in a cohort of 375 patients undergoing bariatric surgery (BS). To evaluate weight response, we combined several variables to define specific response phenotypes six years after surgery. The study protocol was registered in ISRCTN (ID80961259). The analysis of the selected SNPs was performed via allelic discrimination using Taqman^® probes (Applied Biosystems, Foster City, CA, USA). The genotype associati

SUBMITTER: Torrego-Ellacuria M 

PROVIDER: S-EPMC10342460 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature