Ontology highlight
ABSTRACT:
SUBMITTER: Park HS
PROVIDER: S-EPMC10342552 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Park Hang-Soo HS Cetin Esra E Siblini Hiba H Seok Jin J Alkelani Hiba H Alkhrait Samar S Liakath Ali Farzana F Mousaei Ghasroldasht Mohammad M Beckman Analea A Al-Hendy Ayman A
International journal of molecular sciences 20230706 13
Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in women. Previously, we suggested that human mesenchymal stem cells (MSCs) can reverse the PCOS condition by secreting factors. Here, we evaluated the therapeutic capability of MSC-derived extracellular vesicles (EVs), also known as exosomes, in both in vitro and in vivo PCOS models. Exosomes were used to treat androgen-producing H293R cells and injected in a mouse model through intraovarian and intravenous injectio ...[more]