Effect of Trace Metal Ions on the Conformational Stability of the Visual Photoreceptor Rhodopsin.

ABSTRACT: Trace metals are essential elements that play key roles in a number of biochemical processes governing human visual physiology in health and disease. Several trace metals, such as zinc, have been shown to play important roles in the visual phototransduction process. In spite of this, there has been little research conducted on the direct effect of trace metal elements on the visual photoreceptor rhodopsin. In the current study, we have determined the effect of several metal ions, such as iron, copper, chromium, manganese, and nickel, on the conformational stability of rhodopsin. To this aim, we analyzed, by means of UV-visible and fluorescence spectroscopic methods, the effects of these trace elements on the thermal stability of dark rhodopsin, the stability of its active Metarhodopsin II

SUBMITTER: Wang F 

PROVIDER: S-EPMC10342768 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature