AB Toxins as High-Affinity Ligands for Cell Targeting in Cancer Therapy.

ABSTRACT: Conventional targeted therapies for the treatment of cancer have limitations, including the development of acquired resistance. However, novel alternatives have emerged in the form of targeted therapies based on AB toxins. These biotoxins are a diverse group of highly poisonous molecules that show a nanomolar affinity for their target cell receptors, making them an invaluable source of ligands for biomedical applications. Bacterial AB toxins, in particular, are modular proteins that can be genetically engineered to develop high-affinity therapeutic compounds. These toxins consist of two distinct domains: a catalytically active domain and an innocuous domain that acts as a ligand, directing the catalytic domain to the target cells. Interestingly, many tumor cells show receptors on the surfa

SUBMITTER: Marquez-Lopez A 

PROVIDER: S-EPMC10343017 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature