A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity.

ABSTRACT: Coronary artery disease (CAD), type 2 diabetes (T2D) and depression are among the leading causes of chronic morbidity and mortality worldwide. Epidemiological studies indicate a substantial degree of multimorbidity, which may be explained by shared genetic influences. However, research exploring the presence of pleiotropic variants and genes common to CAD, T2D and depression is lacking. The present study aimed to identify genetic variants with effects on cross-trait liability to psycho-cardiometabolic diseases. We used genomic structural equation modelling to perform a multivariate genome-wide association study of multimorbidity (Neffective = 562,507), using summary statistics from univariate genome-wide association studies for CAD, T2D and major depression. CAD was moderately genetically

SUBMITTER: Baltramonaityte V 

PROVIDER: S-EPMC10343069 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature