The Prediction of Antioxidant Q-Markers for Angelica dahurica Based on the Dynamics Change in Chemical Compositions and Network Pharmacology.

ABSTRACT:

Objective

To clarify the accumulation and mutual transformation patterns of the chemical components in Angelica dahurica (A. dahurica) and predict the quality markers (Q-Markers) of its antioxidant activity.

Method

The types of and content changes in the chemical components in various parts of A. dahurica during different periods were analyzed by using gas chromatography-mass spectrometry technology (GC-MS). The antioxidant effect of the Q-Markers was predicted using network pharmacological networks, and molecular docking was used to verify the biological activity of the Q-Markers.

Result

The differences in the content changes in the coumarin compounds in different parts were found by using GC-MS technology, with the relative content being the bes

SUBMITTER: Gao H 

PROVIDER: S-EPMC10343566 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature