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Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance.

ABSTRACT: Four polyoxygenated stigmastanes (1-4) alongside known analogues (7-8) and flavonoids (5-6) were isolated from a dichloromethane/methanol (1:1, v/v) extract of the whole plant of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Their structures were determined by means of spectroscopic and spectrometric analysis. The relative stereochemistry of the new compounds was established and confirmed via biosynthesis evidence and cyclization of 1 under acidic conditions. A plausible biosynthetic pathway to the new compounds and the chemophenetic significance of the isolated constituents were also discussed. The crude extract, fractions, and compounds (1-3) were assessed for their antibacterial activity against five highly prevalent bacterial strains. The fractions and compounds showed low to moderate activity with minimal inhibitory concentrations (MICs) > 125 µg/mL.

SUBMITTER: Tseme Wandji N 

PROVIDER: S-EPMC10343579 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Polyoxygenated Stigmastane-Type Steroids from <i>Vernonia kotschyana</i> Sch. Bip. ex Walp. and Their Chemophenetic Significance.

Tseme Wandji Nadine N   Bitchagno Gabin Thierry M GTM   Mawabo Kamga Isabelle I   Tchamgoue Joseph J   Nkenfou Celine Nguefeu CN   Lenta Bruno Ndjakou BN   Sewald Norbert N   Kouam Simeon Fogue SF  

Molecules (Basel, Switzerland) 20230707 13

Four polyoxygenated stigmastanes (<b>1</b>-<b>4</b>) alongside known analogues (<b>7</b>-<b>8</b>) and flavonoids (<b>5</b>-<b>6</b>) were isolated from a dichloromethane/methanol (1:1, <i>v</i>/<i>v</i>) extract of the whole plant of <i>Vernonia kotschyana</i> Sch. Bip. ex Walp. (Asteraceae). Their structures were determined by means of spectroscopic and spectrometric analysis. The relative stereochemistry of the new compounds was established and confirmed via biosynthesis evidence and cyclizat  ...[more]

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