Ontology highlight
ABSTRACT:
SUBMITTER: Sun YJ
PROVIDER: S-EPMC10343641 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Sun Yi-Jing YJ Gong Ya-Ling YL Lu Shi-Chao SC Zhang Shi-Peng SP Xu Shu S
Molecules (Basel, Switzerland) 20230621 13
Pynegabine, an antiepileptic drug candidate in phase I clinical trials, is a structural analog of the marketed drug retigabine with improved chemical stability, strong efficacy, and a better safety margin. The reported shortest synthetic route for pynegabine contains six steps and involves the manipulation of highly toxic methyl chloroformate and dangerous hydrogen gas. To improve the feasibility of drug production, we developed a concise, three-step process using unconventional methoxycarbonyla ...[more]