Neuronally expressed PDL1, not PD1, suppresses acute nociception.

ABSTRACT: PDL1 is a protein that induces immunosuppression by binding to PD1 expressed on immune cells. In line with historical studies, we found that membrane-bound PD1 expression was largely restricted to immune cells; PD1 was not detectable at either the mRNA or protein level in peripheral neurons using single neuron qPCR, immunolabeling and flow cytometry. However, we observed widespread expression of PDL1 in both sensory and sympathetic neurons that could have important implications for patients receiving immunotherapies targeting this pathway that include unexpected autonomic and sensory related effects. While signaling pathways downstream of PD1 are well established, little to no information is available regarding the intracellular signaling downstream of membrane-bound PDL1 (also known as re

SUBMITTER: Meerschaert KA 

PROVIDER: S-EPMC10343937 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature