Assessing monocyte phenotype in poly(γ-glutamic acid) hydrogels formed by orthogonal thiol-norbornene chemistry.

ABSTRACT: Hydrogels with tunable properties are highly desirable in tissue engineering applications as they can serve as artificial extracellular matrix to control cellular fate processes, including adhesion, migration, differentiation, and other phenotypic changes via matrix induced mechanotransduction. Poly(γ-glutamic acid) (PGA) is an natural anionic polypeptide that has excellent biocompatibility, biodegradability, and water solubility. Moreover, the abundant carboxylic acids on PGA can be readily modified to introduce additional functionality or facilitate chemical crosslinking. PGA and its derivatives have been widely used in tissue engineering applications. However, no prior work has explored orthogonal crosslinking of PGA hydrogels by thiol-norbornene (NB) chemistry. In this study, we

SUBMITTER: Kim MH 

PROVIDER: S-EPMC10344423 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature