Low-level repressive histone marks fine-tune gene transcription in neural stem cells.

ABSTRACT: Coordinated regulation of gene activity by transcriptional and translational mechanisms poise stem cells for a timely cell-state transition during differentiation. Although important for all stemness-to-differentiation transitions, mechanistic understanding of the fine-tuning of gene transcription is lacking due to the compensatory effect of translational control. We used intermediate neural progenitor (INP) identity commitment to define the mechanisms that fine-tune stemness gene transcription in fly neural stem cells (neuroblasts). We demonstrate that the transcription factor Fruitless^C (Fru^C) binds cis-regulatory elements of most genes uniquely transcribed in neuroblasts. Loss of fru^C function alone has no effect on INP commitment but drive

SUBMITTER: Rajan A 

PROVIDER: S-EPMC10344426 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature