The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression.

ABSTRACT:

Background and aims

The NADPH oxidase NOX4 plays a tumor-suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in xenografts in mice. NOX4 gene deletions are frequent in HCC, correlating with higher tumor grade and worse recurrence-free and overall survival rates. However, despite the accumulating evidence of a protective regulatory role in HCC, the cellular processes governed by NOX4 are not yet understood. Accordingly, the aim of this work was to better understand the molecular mechanisms regulated by NOX4 in HCC in order to explain its tumor-suppressor action.

Approach and results

Experimental models: cell-based loss or gain of NOX4 function experiments, in vivo hepatoc

SUBMITTER: Penuelas-Haro I 

PROVIDER: S-EPMC10344438 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature