Exploration of the association between the single-nucleotide polymorphism of co-stimulatory system and rheumatoid arthritis.

ABSTRACT:

Introduction

The human leukocyte antigen (HLA) has been linked to the majority of autoimmune diseases (ADs). However, non-HLA genes may be risk factors for ADs. A number of genes encoding proteins involved in regulating T-cell and B-cell function have been identified as rheumatoid arthritis (RA) susceptibility genes.

Methods

In this study, we investigated the association between RA and single-nucleotide polymorphisms (SNPs) of co-stimulatory or co-inhibitory molecules in 124 RA cases and 100 healthy controls without immune-related diseases [including tumor necrosis factor superfamily member 4 (TNFSF4), CD28, cytotoxic T-lymphocyte-associated protein 4 (CTLA4), and programmed cell death protein 1 (PDCD1)].

Results

The results showed that there were 13 SNPs associated w

SUBMITTER: Chen DP 

PROVIDER: S-EPMC10344454 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature