A novel prognosis prediction of esophageal cancer based on chromatin regulator-related lncRNA.

ABSTRACT: It has been reported that chromatin regulators (CRs), as one of the essential upstream regulators of tumor development, were screened to construct a prognostic model for predicting the outcome of tumor patients. However, the prognostic model based on CRs-related long noncoding RNAs (lncRNAs) in esophageal cancer (EC) has never been researched. This study aims to construct a novel CRs-related lncRNA signature to evaluate the prognostic ability of EC patients. We obtained the transcriptome data and clinical information of patients with EC from the Cancer Genome Atlas database, 870 CRs-related genes from previous topic research. Univariate, multivariate Cox, the least absolute shrinkage and selection operator regression analyses were used to establish the risk model. The receiver operating ch

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10344484 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature