Molecular subtyping and prognostic risk characterization of head and neck squamous cell carcinoma based on lysosome-related genes.

ABSTRACT: Lysosomes possess a multitude of biological functions and are known to play a crucial role in the proliferation and metastasis of head and neck squamous cell carcinoma (HNSCC). This study aims to systematically investigate the potential role of lysosomes-related genes (LRGs) in the development of heterogeneity and prognosis in HNSCC. Publicly available transcriptome and clinical data of HNSCC were obtained and analyzed using consensus clustering to identify molecular subtypes. A risk model based on LRGs was developed and evaluated, including its correlation with clinical features, immune infiltration, drug sensitivity, and response to immune therapy. Gene set enrichment analysis was conducted to explore relevant pathways, and a prognostic nomogram model for HNSCC was constructed and evalua

SUBMITTER: Zhang A 

PROVIDER: S-EPMC10344503 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature