Treating cognitive impairments in primary central nervous system infections: A systematic review of pharmacological interventions.

ABSTRACT:

Background

This research synthesized scientific evidence on the use of pharmacotherapy as intervention to reduce cognitive impairments in adult patients with primary central nervous system (CNS) infections.

Methods

We searched for experimental studies published in English prior to October 2021 in MEDLINE, Embase and Cochrane databases. We included non-randomized studies (NRS) and randomized control trials (RCT) of pharmacotherapy versus placebo, drug, or a combination of drugs in adults with primary CNS infection. The certainty of the evidence was rated according to GRADE guidelines.

Results

We included 8 RCTs and 1 NRS, involving a total of 805 patients (50.77% male patients; mean age 42.67 ± 10.58) with Lyme disease (LD), herpes simplex virus type 1 (HSV-1), or Creu

SUBMITTER: Rizvi ST 

PROVIDER: S-EPMC10344564 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature