Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant.

ABSTRACT:

Background

Lipids serve as multifunctional metabolites that have important implications for the pregnant mother and developing fetus. Abnormalities in lipids have emerged as potential risk factors for pregnancy diseases, such as preeclampsia and fetal growth restriction. The aim of this study was to assess the potential of lipid metabolites for detection of late-onset preeclampsia and fetal growth restriction.

Methods

We used a case-cohort of 144 maternal plasma samples at 36 weeks' gestation from patients before the diagnosis of late-onset preeclampsia (n = 22), delivery of a fetal growth restricted infant (n = 55, defined as <5th birthweight centile), gestation-matched controls (n = 72). We performed liquid chromatography-tandem mass spectrometry (LC-QQQ) -based targeted l

SUBMITTER: Bartho LA 

PROVIDER: S-EPMC10344703 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature