Staged use of ordinal and linear disability scales: a practical approach to granular assessment of acute stroke outcome.

ABSTRACT:

Background

The modified Rankin Scale (mRS) assessment of global disability is the most common primary endpoint in acute stroke trials but lacks granularity (7 broad levels) and is ordinal (scale levels unknown distances apart), which constrains study power. Disability scales that are linear and continuous may better discriminate outcomes, but computerized administration in stroke patients is challenging. We, therefore, undertook to develop a staged use of an ordinal followed by a linear scale practical to use in multicenter trials.

Methods

Consecutive patients undergoing 3-month final visits in the NIH FAST-MAG phase 3 trial were assessed with the mRS followed by 15 mRS level-specific yes-no items of the Academic Medical Center Linear Disability Score (ALDS), a linear disabi

SUBMITTER: Chaisinanunkul N 

PROVIDER: S-EPMC10344771 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature