A novel cuproptosis-related diagnostic gene signature and differential expression validation in atherosclerosis.

ABSTRACT: Atherosclerosis (AS) is a major contributor to morbidity and mortality worldwide. However, the molecular mechanisms and mediator molecules involved remain largely unknown. Copper, which plays an essential role in cardiovascular disease, has been suggested as a potential risk factor. Copper homeostasis is closely related to the occurrence and development of AS. Recently, a new cell death pathway called cuproptosis has been discovered, which is driven by intracellular copper excess. However, no previous studies have reported a relationship between cuproptosis and AS. In this study, we integrated bulk and single-cell sequencing data to screen and identify key cuproptosis-related genes in AS. We used correlation analysis, enrichment analysis, random forest, and other bioinformatics methods to

SUBMITTER: Cui Y 

PROVIDER: S-EPMC10344858 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature