Cortical involvement in essential tremor with and without rest tremor: a machine learning study.

ABSTRACT:

Introduction

There is some debate on the relationship between essential tremor with rest tremor (rET) and the classic ET syndrome, and only few MRI studies compared ET and rET patients. This study aimed to explore structural cortical differences between ET and rET, to improve the knowledge of these tremor syndromes.

Methods

Thirty-three ET patients, 30 rET patients and 45 control subjects (HC) were enrolled. Several MR morphometric variables (thickness, surface area, volume, roughness, mean curvature) of brain cortical regions were extracted using Freesurfer on T1-weighted images and compared among groups. The performance of a machine learning approach (XGBoost) using the extracted morphometric features was tested in discriminating between ET and rET patients.

Results

SUBMITTER: Bianco MG 

PROVIDER: S-EPMC10344993 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature