Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans.

ABSTRACT: Transient stress experiences not only trigger acute stress responses, but can also have long-lasting effects on cellular functions. In Caenorhabditis elegans, a brief exposure to heat shock during early adulthood extends lifespan and improves stress resistance, a phenomenon known as heat hormesis. Here, we investigated the prolonged effect of hormetic heat stress on the transcriptome of worms and found that the canonical heat shock response is followed by a profound transcriptional reprogramming in the post-stress period. This reprogramming relies on the endoribonuclease ENDU-2 but not the heat shock factor 1. ENDU-2 co-localizes with chromatin and interacts with RNA polymerase II, enabling specific regulation of transcription after the stress period. Failure to activate the post-stress re

SUBMITTER: Xu F 

PROVIDER: S-EPMC10345090 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature