Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy.

ABSTRACT: Diabetic Retinopathy (DR) is a complication of diabetes that causes blindness in adults. Retinal fibrosis is closely associated with developing proliferative diabetic retinopathy (PDR). Clinical studies have shown that fibrotic membranes exhibit uncontrolled growth in PDR and contribute to retinal detachment from RPE cells, ultimately leading to vision loss. While anti-VEGF agents and invasive laser treatments are the primary treatments for PDR, retinal fibrosis has received minimal attention as a potential target for therapeutic intervention. Therefore, to investigate the potential role of Akt2 in the diabetes-induced retinal fibrosis process, we generated RPE-specific Akt2 conditional knockout (cKO) mice and induced diabetes in these mice and Akt2^fl/fl control mice by intraper

SUBMITTER: Daley R 

PROVIDER: S-EPMC10345150 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature