Allogeneic haematopoietic cell transplants as dynamical systems: influence of early-term immune milieu on long-term T-cell recovery.

ABSTRACT:

Objectives

Immune recovery following haematopoietic cell transplantation (HCT) functions as a dynamical system. Reducing the duration of intense immune suppression and augmenting antigen presentation has the potential to optimise T-cell reconstitution, potentially influencing long-term outcomes.

Methods

Based on donor-derived T-cell recovery, 26 patients were adaptively randomised between mycophenolate mofetil (MMF) administered for 30-day post-transplant with filgrastim for cytokine support (MMF30 arm, N = 11), or MMF given for 15 days with sargramostim (MMF15 arm, N = 15). All patients underwent in vivo T-cell depletion with 5.1 mg kg^-1 antithymocyte globulin (administered over 3 days, Day -9 through to Day -7) and received reduced intensity

SUBMITTER: Zelikson V 

PROVIDER: S-EPMC10345185 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature