Gastrodia elata and parishin ameliorate aging induced 'leaky gut' in mice: Correlation with gut microbiota.

ABSTRACT:

Background

The aging-induced decrease in intestinal barrier function contributes to many age-related diseases. Studies on preventive measures for "leaky gut" may help improve the quality of life of geriatric patients. The potent anti-aging effect of Gastrodia elata and parishin, which is one of its active ingredients, has been reported previously. However, their effects on the gut remain elusive, and the effect of parishin on mammals has not been studied.

Methods

We used quantitative RT-PCR, western blotting, immunohistochemical analysis, and 16S rRNA sequencing to investigate the effect of G. elata and parishin on the intestinal barrier function of D-Gal-induced aging mice.

Results

G. elata and parishin prevented the decrease in tight junction protein (TJP) expressio

SUBMITTER: Gong CX 

PROVIDER: S-EPMC10345228 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature