Humoral immune responses associated with control of SARS-CoV-2 breakthrough infections in a vaccinated US military population.

ABSTRACT:

Background

COVID-19 vaccines have been critical for protection against severe disease following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but gaps remain in our understanding of the immune responses that contribute to controlling subclinical and mild infections.

Methods

Vaccinated, active-duty US military service members were enrolled in a non-interventional, minimal-risk, observational study starting in May, 2021. Clinical data, serum, and saliva samples were collected from study participants and were used to characterise the humoral immune responses to vaccination and to assess its impact on clinical and subclinical infections, as well as virologic outcomes of breakthrough infections (BTI) including viral load and infection duration.

Fi

SUBMITTER: Gromowski GD 

PROVIDER: S-EPMC10345251 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature