Barrier-forming, drug-free nasal spray reduces allergic symptoms induced by house dust mite allergen.

ABSTRACT:

Background

House Dust Mite (HDM) is the most common indoor allergen triggering allergic symptoms. First-line pharmacotherapy treatment is recommended in international guidelines, while the avoidance of allergens represents a still unmet guideline principle. AM-301 is a new non-pharmacological nasal spray that creates a protective gel-like barrier on the nasal mucosa, preventing the contact with the allergens.

Methods

This randomized, open-label, 3-period crossover study assessed the efficacy and safety of AM-301. The objective was to determine whether AM-301 reduces allergic rhinitis (AR) symptoms in patients exposed to HDM allergens. Adults with confirmed Perennial Allergic Rhinitis (PAR; n = 37) were exposed to HDM allergen in a controlled Allergen Exposure Chamber before

SUBMITTER: Couroux P 

PROVIDER: S-EPMC10345461 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature