Causal relationship between particulate matter 2.5 (PM_2.5), PM_2.5 absorbance, and COVID-19 risk: A two-sample Mendelian randomisation study.

ABSTRACT:

Background

Several observational studies reported on the association between particulate matter ≤2.5μm (PM_2.5) and its absorbance with coronavirus (COVID-19), but none use Mendelian randomisation (MR). To strengthen the knowledge on causality, we examined the association of PM_2.5 and its absorbance with COVID-19 risk using MR.

Methods

We selected genome-wide association study (GWAS) integration data from the UK Biobank and IEU Open GWAS Project for two-sample MR analysis. We used inverse variance weighted (IVW) and its multiple random effects and fixed effects alternatives to generally predict the association of PM_2.5 and its absorbance with COVID-19, and six methods (MR Egger, weighted median, simple mode, weighted mode, maximum-likelihood a

SUBMITTER: Liu C 

PROVIDER: S-EPMC10346132 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature