Associations between Ileal Juice Bile Acids and Colorectal Advanced Adenoma.

ABSTRACT:

Background

There is an urgent need to identify biomarkers for advanced adenoma, an important precursor of colorectal cancer (CRC). We aimed to determine alterations in ileal juice bile acids associated with colorectal advanced adenoma.

Methods

We quantified a comprehensive panel of primary and secondary bile acids and their conjugates using an ultraperformance liquid chromatography triple-quadrupole mass spectrometric assay in ileal juice collected at colonoscopy from 46 study subjects (i.e., 14 biopsy-confirmed advanced adenomas and 32 controls free of adenoma or cancer). Using analysis of covariance (ANCOVA), we examined the differences in bile acid concentrations by disease status, adjusting for age, sex, body mass index, smoking status and type 2 diabetes.

Results

SUBMITTER: Luu HN 

PROVIDER: S-EPMC10346326 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature