Activation of Tm-2² resistance is mediated by a conserved cysteine essential for tobacco mosaic virus movement.

ABSTRACT: The tomato Tm-2² gene was considered to be one of the most durable resistance genes in agriculture, protecting against viruses of the Tobamovirus genus, such as tomato mosaic virus (ToMV) and tobacco mosaic virus (TMV). However, an emerging tobamovirus, tomato brown rugose fruit virus (ToBRFV), has overcome Tm-2² , damaging tomato production worldwide. Tm-2² encodes a nucleotide-binding leucine-rich repeat (NLR) class immune receptor that recognizes its effector, the tobamovirus movement protein (MP). Previously, we found that ToBRFV MP (MP^ToBRFV ) enabled the virus to overcome Tm-2² -mediated resistance. Yet, it was unknown how Tm-2² remained durable against other tobamoviruses, such as TMV and ToMV, for over 60 years. Here

SUBMITTER: Hak H 

PROVIDER: S-EPMC10346382 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature