Missing link between tissue specific expressing pattern of ERβ and the clinical manifestations in LGBLEL.

ABSTRACT:

Purpose

Lacrimal gland benign lymphoepithelial lesion (LGBLEL) is an IgG4-related disease of unknown etiology with a risk for malignant transformation. Estrogen is considered to be related to LGBLEL onset.

Methods

Seventy-eight LGBLEL and 13 control clinical samples were collected and studied to determine the relationship between estrogen and its receptors and LGBLEL development.

Results

The serological analysis revealed no significant differences in the levels of three estrogens be-tween the LGBLEL and control groups. However, immunohistochemical analyses indicated that the expression levels of ERβ and its downstream receptor RERG were relatively lower in LGBLEL samples than in control samples, with higher expression in the lacrimal gland and lower expression in the

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10346852 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature