PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine.

ABSTRACT:

Introduction

T cell-dependent inflammatory response with the upregulation of helper 17 T cells (Th17) and the downregulation of regulatory T cells (Treg) accompanied by the increased production of tumor necrosis alpha (TNFa) is characteristic of inflammatory bowel diseases (IBD). Modulation of T cell response may alleviate the inflammation thus reduce intestinal damage. Poly(ADP-ribose) polymerase-2 (PARP2) plays role in the development, differentiation and reactivity of T cell subpopulations. Our aim was to investigate the potential beneficial effect of T cell-specific PARP2 downregulation in the lipopolysaccharide (LPS) induced inflammatory response of the cecum and the colon.

Methods

Low-dose LPS was injected intraperitoneally to induce local inflammatory response, charac

SUBMITTER: Bencsics M 

PROVIDER: S-EPMC10347374 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature