No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Numerous observational studies have suggested that atrial fibrillation (AF) was associated with an increased risk of vascular dementia (VaD). However, the causal genetic relationships between AF and VaD remains unclear. To evaluate the effect of AF on VaD, we performed the Mendelian randomization (MR) analysis to investigate the causal genetic relationships between AF and VaD.

Methods

The bidirectional MR analysis was conducted to explore the causal relationships between exposure and disease. We applied a series of quality assessments to select significantly and independently single nucleotide polymorphisms (SNPs) from publicly available large-scale genome-wide association studies (GWAS) databases. Three methods [Inverse variance weighted method (IVW), MR-Egger me

SUBMITTER: Gao YF 

PROVIDER: S-EPMC10347408 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature