Frequency specificity of aberrant triple networks in major depressive disorder: a resting-state effective connectivity study.

ABSTRACT: Major depressive disorder (MDD) has been associated with aberrant effective connectivity (EC) among the default mode network (DMN), salience network (SN), and central executive network (CEN)-collectively referred to as triple networks. However, prior research has predominantly concentrated on broad frequency bands (0.01-0.08 Hz or 0.01-0.15 Hz), ignoring the influence of distinct rhythms on triple network causal dynamics. In the present study, we aim to investigate EC alterations within the triple networks across various frequency bands in patients with MDD. Utilizing a data-driven frequency decomposition approach and a multivariate Granger causality analysis, we characterized frequency-specific EC patterns of triple networks in 49 MDD patients and 54 healthy controls. A support vector mac

SUBMITTER: Li Y 

PROVIDER: S-EPMC10347531 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature