Light-Controlled Cell-Cell Assembly Using Photocaged Oligonucleotides.

ABSTRACT: The interactions between heterogeneous cell populations play important roles in dictating various cell behaviors. Cell-cell contact mediates communication through the exchange of signaling molecules, electrical coupling, and direct membrane-linked ligand-receptor interactions. In vitro culturing of multiple cell types with control over their specific arrangement is difficult, especially in three-dimensional (3D) systems. While techniques that allow one to control the arrangement of cells and direct contact between different cell types have been developed that expand upon simple co-culture methods, specific control over heterojunctions that form between cells is not easily accomplished with current methods, such as 3D cell-printing. In this article, DNA-mediated cell interactions are combin

SUBMITTER: Mathis K 

PROVIDER: S-EPMC10347689 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature