A precise molecular subtyping of ulcerative colitis reveals the immune heterogeneity and predicts clinical drug responses.

ABSTRACT:

Background and aims

We sought to identify novel molecular subtypes of ulcerative colitis (UC) based on large-scale cohorts and establish a clinically applicable subtyping system for the precision treatment of the disease.

Methods

Eight microarray profiles containing colon samples from 357 patients were utilized. Expression heterogeneity was screened out and stable subtypes were identified among UC patients. Immune infiltration pattern and biological agent response were compared among subtypes to assess the value in guiding treatment. The relationship between PRLR and TNFSF13B genes with the highest predictive value was further validated by functional experiments.

Results

Three stable molecular subtypes were successfully identified. Immune cell infiltration analysis de

SUBMITTER: Mo S 

PROVIDER: S-EPMC10347743 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature