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A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023.

ABSTRACT: An outbreak of Ralstonia mannitolilytica bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with R. mannitolilytica. Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with R. mannitolilytica infections (attack rate = 34%; 95% confidence interval: 22.1-47.4). Discontinuation of the contaminated urokinase terminated the outbreak.

SUBMITTER: Fabricci M 

PROVIDER: S-EPMC10347894 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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A urokinase-associated outbreak of <i>Ralstonia mannitolilytica</i> bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023.

Fabricci Massimiliano M   Trinca Anaïs A   Talotti Luca L   Busetti Marina M   Fotakis Emmanouil Alexandros EA   Merakou Christina C   Koncan Raffaella R   Ghiotti Annachiara A   Negri Camilla C   Di Maso Vittorio V   Bosco Manuela M   Antonelli Alberto A   Coppi Marco M   Rossolini Gian Maria GM   Giuliani Claudia C   Scarpis Enrico E   Gregoretti Barbara B   Licastro Danilo D   Luzzati Roberto R   Costantino Venera V  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20230701 28

An outbreak of <i>Ralstonia mannitolilytica</i> bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with <i>R. mannitolilytica.</i> Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with <i>R. mannitolilytica</i> i  ...[more]

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