Bioflavonoid luteolin prevents sFlt-1 release via HIF-1α inhibition in cultured human placenta.

ABSTRACT: Preeclampsia (PE) is a serious hypertensive complication of pregnancy and is a leading cause of maternal death and major contributor to maternal and perinatal morbidity, including establishment of long-term complications. The continued prevalence of PE stresses the need for identification of novel treatments which can target prohypertensive factors implicated in the disease pathophysiology, such as soluble fms-like tyrosine kinase 1 (sFlt-1). We set out to identify novel compounds to reduce placental sFlt-1 and determine whether this occurs via hypoxia-inducible factor (HIF)-1α inhibition. We utilized a commercially available library of natural compounds to assess their ability to reduce sFlt-1 release from primary human placental cytotrophoblast cells (CTBs). Human placental explants from

SUBMITTER: Eddy AC 

PROVIDER: S-EPMC10348062 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature