Biological role and diagnostic utility of ribosomal protein L23a pseudogene 53 in cutaneous melanoma.

ABSTRACT:

Background

Skin melanoma is one of the deadliest types of skin cancer and develops from melanocytes. The genetic aberrations in protein-coding genes are well characterized, but little is known about changes in non-coding RNAs (ncRNAs) such as pseudogenes. Ribosomal protein pseudogenes (RPPs) have been described as the largest group of pseudogenes which are dispersed in the human genome.

Materials and methids

We looked deeply at the role of one of them, ribosomal protein L23a pseudogene 53 (RPL23AP53), and its potential diagnostic use. The expression level of RPL23AP53 was profiled in melanoma cell lines using real time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and analyzed based on the Cancer Genome Atlas (TCGA) data depending on

SUBMITTER: Kolenda T 

PROVIDER: S-EPMC10348336 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature