Ontology highlight
ABSTRACT:
SUBMITTER: Gu Y
PROVIDER: S-EPMC10348683 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Gu Yuanzhuo Y Zhang Zhengkui Z Camps Marcel G M MGM Ossendorp Ferry F Wijdeven Ruud H RH Ten Dijke Peter P
Science advances 20230714 28
The genetic circuits that allow cancer cells to evade immune killing via epithelial mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like (Mes) KPC3 pancreatic cancer cells were more resistant to cytotoxic T lymphocyte (CTL)-mediated killing than the parental epithelial-like (Epi) cells and used parallel genome-wide CRISPR screens to assess the molecular underpinnings of this difference. Core CTL-evasion genes (such as IFN-γ pathway components) were clearly evide ...[more]