Gastrointestinal microbiome of ARDS patients induces neuroinflammation and cognitive impairment in mice.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a respiratory failure syndrome that can cause many complications, impacting patients' quality of life. Behavioral and cognitive disorders have attracted increasing attention in patients with ARDS, but its potential mechanisms are still elusive.

Methods

Herein we transferred the faecal microbiota from patients with ARDS caused by community-acquired pneumonia (CAP) to antibiotics-treated recipient male mice to explore the microbiota-gut-brain mechanisms. Behavioral functions of mice were evaluated by the open field test, Morris water maze and Y-maze test. The structure and composition of the gut microbiota were analyzed by using 16S rRNA sequencing analysis. Microglia, astrocyte and neuron in the cortex and hippocampus w

SUBMITTER: Zheng H 

PROVIDER: S-EPMC10349492 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature