Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets.

ABSTRACT:

Objectives

Epidemiological studies have confirmed that low birth weight (BW) is related to neuroticism and they may have a common genetic mechanism based on phenotypic correlation research. We conducted our study on a European population with 159,208 neuroticism and 289,142 birth weight samples. In this study, we aimed to identify new neuroticism single nucleotide polymorphisms (SNPs) and pleiotropic SNPs associated with neuroticism and BW and to provide more theoretical basis for the pathogenesis of the disease.

Methods

We estimated the pleiotropic enrichment between neuroticism and BW in two independent Genome-wide association studies (GWAS) when the statistical thresholds were Conditional False Discovery Rate (cFDR) < 0.01 and Conjunctional Conditional False Discovery Rat

SUBMITTER: Zhou XY 

PROVIDER: S-EPMC10349512 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature