Identification of a new prognostic score for patients with high-grade metastatic GEP-NEN treated with palliative chemotherapy.

ABSTRACT:

Purpose

High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN G3) are rare and heterogeneous malignancies with poor prognosis. Aim of this study was to develop prognosticators identifying those patients that derive the most benefit from currently available systemic therapies.

Methods

This retrospective analysis included 78 patients with metastatic GEP-NEN G3. For patients with imaging data available (n = 52), the overall response rate (ORR) and disease control rate (DCR) were evaluated according to the Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1). A Cox proportional hazard model was used to analyze the prognostic value of selected clinical and blood-based biomarkers. The impact of palliative chemotherapy regimens on time-to-treatment-failure (T

SUBMITTER: Rosery V 

PROVIDER: S-EPMC10349702 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature