Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.

ABSTRACT:

Purpose

Prostate cancer (PC) is successfully treated with anti-androgens; however, a significant proportion of patients develop resistance against this therapy. Anti-androgen-resistant disease (castration-resistant prostate cancer; CRPC) is currently incurable. Cyclin-dependent kinase 7 (CDK7) is positioned to positively regulate both cell cycle and transcription, the two features critical for the rapid proliferation of the CRPC cells. Here, we assess if CDK7 is a viable target to halt the proliferation of CRPC cells.

Methods

We use recently developed clinically relevant compounds targeting CDK7 and multiple cell proliferation assays to probe the importance of this kinase for the proliferation of normal, androgen-dependent, and CRPC cells. PC patient data were used to evalua

SUBMITTER: Pallasaho S 

PROVIDER: S-EPMC10349716 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature