Immunomodulatory effects of carbon ion radiotherapy in patients with localized prostate cancer.

ABSTRACT:

Purpose

Radiotherapy is one of the main local treatment modalities for prostate cancer, while immunosuppressive effect induced by radiotherapy is an important factor of radiation resistance and treatment failure. Carbon ion radiotherapy (CIRT) is a novel radiotherapy technique and the immunomodulatory effect of CIRT provides the possibility of overcoming radioresistance and improving efficacy. The aim of this study was to assess the immune response evoked by CIRT in localized prostate cancer patients.

Methods

Thirty-two patients were treated by CIRT combined with or without hormone therapy and peripheral blood samples were collected before and after CIRT. Investigation of peripheral immune cell frequency, proliferation, and cytokine expression was conducted by flow cytometry

SUBMITTER: Hu W 

PROVIDER: S-EPMC10349746 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature